Dexamethasone

SIGMA/D1756 - ≥98% (HPLC), powder

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F

CAS Number: 50-02-2
Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
Molecular Weight: 392.46
EC Number: 200-003-9
MDL Number: MFCD00064136
Linear Formula: C₂₂H₂₉FO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D1756-25MG	25 mg	$39.80 1/EA	Add To Favorites
45-D1756-100MG	100 mg	$94.50 1/EA	Add To Favorites
45-D1756-500MG	500 mg	$257.00 1/EA	Add To Favorites
45-D1756-1G	1 g	$397.00 1/EA	Add To Favorites
45-D1756-5G	5 g	$1540.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1756-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white
form	powder
InChI	1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key	UREBDLICKHMUKA-CXSFZGCWSA-N
mp	262-264 °C (lit.)
originator	Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level	200
SMILES string	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
solubility	methanol: 25 mg/mL
storage temp.	2-8°C

Application:	Dexamethasone has been used: • in culture media to induce differentiation of adipose-derived stem cells into osteogenic tissue • as a component of adipocyte differentiation medium • for in vitro stimulation of primary normal human bronchial epithelial cells (NHBE) and airway smooth muscle (ASM)
Biochem/physiol Actions:	Dexamethasone is known to be effective against relapsed multiple myeloma. It is found to decrease inflammation associated with cerebrospinal fluid and central nervous system (CNS) complications, such as hearing loss.
Biochem/physiol Actions:	Glucocorticoid anti-inflammatory agent
Biochem/physiol Actions:	Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Dexamethasone is a potent glucocorticoid with minimal to no mineralocorticoid activity. Dexamethasone exhibits pleiotropic effects on multiple signaling pathways, some of its functions include, inhibition of neutrophil migration and reduction of lymphocyte colony proliferation. Research findings show, dexamethasone might prevent high-altitude pulmonary edema by decreasing pulmonary artery pressure.
Packaging:	1, 5 g in glass bottle
Packaging:	25, 100, 500 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note:	Dexamethasone is soluble in DMSO (25 mg/ml), chloroform or ethanol.
Preparation Note:	Dilute 1 mg/ml stock solution 1:50 with sterile media and store frozen in working aliquots to avoid repeated freeze-thaw.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360FD
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	22-26-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	262-264 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	51422306

To Order From a Quote