Doxycycline monohydrate

SIGMA/D1822

Synonym: 6-Deoxy-5-oxytetracycline monohydrate; Doxycycline

CAS Number: 17086-28-1
Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₈· H₂O
Molecular Weight: 462.45
MDL Number: MFCD02682958
Linear Formula: C₂₂H₂₄N₂O₈· H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-D1822-500MG	500 mg	$84.70 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycoplasma
	parasites
form	powder or crystals
InChI	1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key	XQTWDDCIUJNLTR-CVHRZJFOSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
storage temp.	−20°C

Application:	• In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1). • It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines. • It has also been used as an antimicrobial agent.
Biochem/physiol Actions:	Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 + P330 - P501
Hazard Codes	Xn
Risk Statements	63-22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	51284030

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