Advanced Search



5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside

SIGMA/D1916

Synonym: 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole; 5,6-Dichlorobenzimidazole riboside; DRB

CAS Number: 53-85-0
Empirical Formula (Hill Notation): C12H12Cl2N2O4
Molecular Weight: 319.14
MDL Number: MFCD00036785
Linear Formula: C12H12Cl2N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D1916-10MG 10 mg
 $73.00
1/EA		 Add To Favorites
45-D1916-50MG 50 mg
 $206.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D1916-50MG

 

form powder
InChI 1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI key XHSQDZXAVJRBMX-DDHJBXDOSA-N
Quality Level 200 
SMILES string OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3cc(Cl)c(Cl)cc23
storage temp. −20°C
Application: 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside has been used:
• as an inhibitor of RNA polymerase II in mouse melanoma cells
• for the inhibition of cyclin D1 mRNA synthesis in human prostate epithelial cell lines
• in the inhibition of interleukin-2 gene transcription in Jurkat cells
Biochem/physiol Actions: 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), a nucleoside analog that halts mRNA synthesis by phosphorylation of the C-terminal domain of RNA polymerase II, making it inactive. It also interferes with the DNA topoisomerase II, may modulate response to cytokines and blocks the human immunodeficiency virus (HIV) via RNA modification. It also inhibits cyclin-dependent kinases (CDKs) 7 and 9 and favors apoptosis in leukemic cells. It may serve as a therapeutic agent in treating cancer.
Biochem/physiol Actions: Inhibitor of RNA synthesis; causes premature termination of transcription. CK2 (casein kinase-2) inhibitor.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 10 mg in poly bottle
Packaging: 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top