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D4476

SIGMA/D1944 - ≥98% (HPLC), solid

Synonym: 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

CAS Number: 301836-43-1
Empirical Formula (Hill Notation): C23H18N4O3
Molecular Weight: 398.41
MDL Number: MFCD28391149
Linear Formula: C23H18N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D1944-1MG 1 mg
 $245.00
1/EA		 Add To Favorites
45-D1944-5MG 5 mg
 $970.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color light yellow
form solid
InChI 1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChI key DPDZHVCKYBCJHW-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
solubility DMSO: ~20 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.
Biochem/physiol Actions: D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
Biochem/physiol Actions: D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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