6-Diazo-5-oxo-L-norleucine

SIGMA/D2141 - powder

Synonym: (S)-2-Amino-6-diazo-5-oxocaproic acid; DON

CAS Number: 157-03-9
Empirical Formula (Hill Notation): C₆H₉N₃O₃
Molecular Weight: 171.15
MDL Number: MFCD00037218
Linear Formula: C₆H₉N₃O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-D2141-5MG	5 mg	$80.90 1/EA		Add To Favorites
45-D2141-25MG	25 mg	$280.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥95% (HPLC)
color	faint yellow, to yellow or tan
form	powder
InChI	1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
InChI key	YCWQAMGASJSUIP-YFKPBYRVSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
storage temp.	−20°C
technique(s)	ligand binding assay: suitable

Application:	6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.
Biochem/physiol Actions:	6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.
Biochem/physiol Actions:	DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.
Biochem/physiol Actions:	DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
General description:	Chemical structure: amino acid derivatives

Symbol	GHS06
Signal word	Danger
Hazard statements	H301 + H311 + H331
Precautionary statements	P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
Hazard Codes	T
Risk Statements	23/24/25
Safety Statements	36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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