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Dacarbazine

SIGMA/D2390 - antineoplastic purine analog

Synonym: 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; DTIC

CAS Number: 4342-03-4
Empirical Formula (Hill Notation): C6H10N6O
Molecular Weight: 182.18
EC Number: 224-396-1
MDL Number: MFCD00057167
Linear Formula: C6H10N6O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D2390-100MG 100 mg
 $104.00
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45-D2390-1G 1 g
 $484.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D2390-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D2390-1G

 

antibiotic activity spectrum neoplastics
form powder or crystals
InChI 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key FDKXTQMXEQVLRF-ZHACJKMWSA-N
mode of action DNA synthesis | interferes
Quality Level 100 
SMILES string CN(C)N=Nc1[nH]cnc1C(N)=O
solubility 1 M HCl: 50 mg/mL
storage temp. 2-8°C
Application: Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
Biochem/physiol Actions: Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Packaging: 1 g in glass bottle
Packaging: 100 mg in glass bottle
Storage Temp. 2-8°C
UNSPSC 51102829

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