(+)-cis-Diltiazem hydrochloride

SIGMA/D2521 - ≥99% (HPLC)

Synonym: (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride; CRD-401

CAS Number: 33286-22-5
Empirical Formula (Hill Notation): C₂₂H₂₆N₂O₄S · HCl
Molecular Weight: 450.98
EC Number: 251-443-3
MDL Number: MFCD00069252
Linear Formula: C₂₂H₂₆N₂O₄S · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D2521-1G	1 g	$122.00 1/EA	Add To Favorites
45-D2521-5G	5 g	$513.00 1/EA	Add To Favorites
45-D2521-10G	10 g	$811.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D2521-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
form	powder
InChI	1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key	HDRXZJPWHTXQRI-BHDTVMLSSA-N
originator	Valeant
Quality Level	200
SMILES string	Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
storage temp.	2-8°C

Application:	(+)-cis-Diltiazem hydrochloride has been used: • to study its effects on diffusion and release in monolithic dispersion matrix(26) • to study its neuroprotective effects in retinitis pigmentosa (RP) models(27) • as an antagonist against the Cav1.2 L-type calcium channels (LTCCs)(28)
Biochem/physiol Actions:	Blocks slow, or L-type Ca²⁺ channels; regulates Ca²⁺ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca²⁺ channels; coronary vasodilator.
Features and Benefits:	This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Calcium Channels and Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Valeant . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Diltiazem hydrochloride is used to treat cardiovascular diseases, such as angina and hypertension. It acts as an inhibitor to cytochrome P450 3A (CYP3A). Diltiazem might be associated with maculopapular rashes, urticaria and pruritus.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	1, 5, 10 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 + P330 - P501
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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