cis-4,7,10,13,16,19-Docosahexaenoic acid

SIGMA/D2534 - ≥98%

Synonym: DHA

CAS Number: 6217-54-5
Empirical Formula (Hill Notation): C₂₂H₃₂O₂
Molecular Weight: 328.49
MDL Number: MFCD00065722
Linear Formula: C₂₂H₃₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D2534-25MG	25 mg	$65.30 1/EA	Add To Favorites
45-D2534-100MG	100 mg	$195.00 1/EA	Add To Favorites
45-D2534-1G	1 g	$678.00 1/EA	Add To Favorites

Representative of vacuum-sealed amber ampule packaging. Non-uniform tips are an inherent feature in this sealing process.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
biological source	algae
form	liquid
functional group	carboxylic acid
InChI	1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChI key	MBMBGCFOFBJSGT-KUBAVDMBSA-N
lipid type	omega FAs
Quality Level	200
shipped in	dry ice
SMILES string	CC/C=CC/C=CC/C=CC/C=CC/C=CC/C=CCCC(O)=O
storage temp.	−20°C

Application:	cis-4,7,10,13,16,19-Docosahexaenoic acid has been used: • as a component in Dulbecco′s modified Eagle medium (DMEM) for culturing cells to perform docosahexaenoic acid (DHA) treatment • to study its impact on human induced pluripotent stem cell (iPSC)-derived neuronal at a molecular and cellular level • in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay to study its cytotoxic effects on three human hepatocellular carcinoma (HCC) cell lines (HepG2, Hep3B, Huh7)
Biochem/physiol Actions:	Docosahexaenoic acid (DHA) participates in the growth and physiology of the central nervous system. It regulates adult neurogenesis and neuroplasticity. DHA plays a key role in fetal brain development. It may exhibit antioxidant and anti-inflammatory properties. DHA plays a role in the regulation of cell membrane fluidity. It plays a vital role in several brain development processes, including neurotransmitter release, gene expression, myelination, neuroinflammation, and neuronal differentiation. DHA possesses an anticancer effect in several types of cancer.
Biochem/physiol Actions:	Docosahexaenoic acid (DHA) serves as a precursor for signaling molecules such as prostaglandins and eicosanoids.
General description:	Docosahexaenoic acid (DHA) is abundantly present in the brain.
General description:	Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid with 22 carbons and six double bonds, the first double bond occurring at position three from the methyl terminus (22:6 n-3). It is a component of lipid membranes and myelin sheath.
Packaging:	1 g in ampule
Packaging:	25, 100 mg in ampule
Packaging:	Sealed ampule.

RIDADR	NA 1993 / PGIII
WGK Germany	WGK 3
Flash Point(F)	143.6 °F - closed cup
Flash Point(C)	62 °C - closed cup

Purity	≥98%
Storage Temp.	−20°C
UNSPSC	12352211

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