Diphenyleneiodonium chloride
SIGMA/D2926 - ≥98%
Synonym: DPI; Dibenziodolium chloride
CAS Number: 4673-26-1
Empirical Formula (Hill Notation): C12H8ClI
Molecular Weight: 314.55
MDL Number: MFCD00214165
Linear Formula: C12H8ClI
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D2926-50MG
| assay | ≥98% |
| form | powder |
| InChI | 1S/C12H8I.ClH/c1-3-7-11-9 |
| InChI key | FCFZKAVCDNTYID-UHFFFAOYSA |
| mp | 278 °C |
| Quality Level | 300  |
| SMILES string | [Cl-].[I+]1c2ccccc2-c3ccc |
| solubility | DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow |
| storage temp. | room temp |
| Application: | Diphenyleneiodonium chloride has been used as an NOX inhibitor: • to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples • as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL) • as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells |
| Biochem/physiol Actions: | A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase. |
| Biochem/physiol Actions: | A potent reversible nitric oxide synthetase inhibitor from macrophages and endothelial cells. |
| Biochem/physiol Actions: | Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation. |
| Packaging: | 10 mg in poly bottle |
| Packaging: | 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| mp | 278 °C |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |