Dipeptidyl Peptidase IX human
SIGMA/D3071 - recombinant, expressed in Sf9 cells
Product Type: Chemical
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| form | solution |
| Quality Level | 200  |
| recombinant | expressed in Sf9 cells |
| shipped in | dry ice |
| specific activity | ≥250 units/μg protein |
| storage temp. | −70°C |
| Application: | DPP9 is a protease of the DPP4 gene family that is used in cancer research to study the regulation of survival and proliferation pathways. DPP9 is used to study cell-extracellular matrix interactions and tissue remodeling. |
| Biochem/physiol Actions: | DPP IX is a member of the S9b family of dipeptidyl peptidases and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. It has a role in regulating cell survival and proliferation through modulating molecular signaling cascades. Protein kinase B activation is significantly inhibited by human DPP9 overexpression in human hepatoma cells (HepG2 and Huh7) and human embryonic kidney cells (HEK293T). DPP9 is thought to influence cell-extracellular matrix interactions and may be involved in the regulation of tissue remodeling . |
| General description: | Full length sequence with an N-terminal GST tag |
| Other Notes: | DPP IX is a member of the S9b family of dipeptidyl peptidases. and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. |
| Other Notes: | One unit will hydrolyze 1.0 picomole of H-Gly-Pro-AMC per minute at pH 7.5 at 25 deg °C |
| Physical form: | Supplied as a solution in 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and 16 mM glutathione |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥250 units/μg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |