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Doxycycline Hydrochloride, Ready Made Solution

SIGMA/D3072 - 100 mg/mL in DMSO, ≥95.0% (HPLC)

Synonym: α-6-Deoxy-5-hydroxytetracycline hydrochloride; α-6-Deoxy-5-hydroxytetracycline hydrochloride; 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-; Doxylin; Idocyklin; Vibramycin hyclate; Vibramycin hydrochloride

CAS Number: 10592-13-9
Empirical Formula (Hill Notation): C22H24N2O8 · HCl
Molecular Weight: 480.90
MDL Number: MFCD03427564
Linear Formula: C22H24N2O8 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D3072-1ML 1 mL
 $55.10
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antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  mycoplasma
  parasites
assay ≥95.0% (HPLC)
biological source synthetic
concentration 100 mg/mL in DMSO
form liquid
InChI 1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key VLUQVUWDECWBTL-UQVCFKGQSA-N
mode of action protein synthesis | interferes
Quality Level 200 
solubility DMSO: 100 mg/mL
sterility 0.22 μm filtered
storage temp. −20°C
Application: <ul>
<li><strong>AAPS PharmSciTech: </strong>Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024 ).</li>
<li><strong>European Journal of Pharmacology: </strong>Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024 ).</li>
</ul>
General description: Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
RIDADR NA 1993 / PGIII
WGK Germany WGK 3
Flash Point(F) 188.6 °F - closed cup
Flash Point(C) 87 °C - closed cup
Purity ≥95.0% (HPLC)
Storage Temp. −20°C
UNSPSC 51284028

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