Dipeptidyl Peptidase VIII human
SIGMA/D3196 - recombinant, expressed in Sf9 cells
Product Type: Chemical
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| concentration | ≥0.08 mg/mL |
| form | solution |
| mol wt | 100 kDa |
| Quality Level | 200  |
| recombinant | expressed in Sf9 cells |
| shipped in | dry ice |
| specific activity | ≥20 units/μg protein |
| storage temp. | −70°C |
| Application: | Human dipeptidyl peptidase VIII has been used in a study to identify ERGIC-53 as an intracellular transport receptor of α1-antitrypsin. Human dipeptidyl peptidase VIII has also been used in a study to investigate the cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. |
| Biochem/physiol Actions: | Dipeptidyl peptidase VIII (DPP8) is a 100 kDa monomeric protein expressed in the cytoplasm. It is a postproline dipeptidyl aminopeptidase that is homologous to DPPIV and fibroblast activation protein (FAP). It hydrolyzes Ala-Pro, Arg-Pro and Gly-Pro. DPP8 has a neutral pH optimum. It may be involved in T-cell activation and immune function as it is similar to DPPIV . It is upregulated during immune activation. |
| General description: | Full length sequence with an N-terminal GST tag |
| Other Notes: | One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C |
| Physical form: | Supplied as a solution in 40 mM Tris-HCL, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT and 20% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| activity | specific activity: ≥20 units/μg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |