Dipeptidyl Peptidase VII human
SIGMA/D3321 - recombinant, expressed in Sf9 cells
Synonym: DPP7; Quiescent cell proline dipeptidase
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| form | solution |
| mol wt | 89.1 kDa |
| Quality Level | 200  |
| recombinant | expressed in Sf9 cells |
| relevant disease(s) | diabetes; cardiovascular diseases |
| shipped in | dry ice |
| specific activity | ≥1,500 units/μg protein |
| ≥1500 units/μg protein | |
| storage temp. | −70°C |
| Application: | Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes . DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research . |
| Biochem/physiol Actions: | DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 . DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. |
| General description: | Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa |
| Other Notes: | One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C |
| Physical form: | Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol. |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥1,500 units/μg protein; specific activity: ≥1500 units/μg protein |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 3.4.14.- |
| UNSPSC | 12352204 |