3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)
SIGMA/D3669 - powder
Synonym: DTSP; Di(N-succinimidyl) 3,3′-dithiodipropionate; Dithiobis(succinimidyl propionate); Lomant’s reagent
CAS Number: 57757-57-0
Empirical Formula (Hill Notation): C14H16N2O8S2
Molecular Weight: 404.42
EC Number: 260-931-5
MDL Number: MFCD00042045
Linear Formula: C14H16N2O8S2
Product Type: Chemical
| form | powder |
| InChI | 1S/C14H16N2O8S2/c17-9-1-2 |
| InChI key | FXYPGCIGRDZWNR-UHFFFAOYSA |
| Quality Level | 200  |
| reaction suitability | reagent type: cross-linking reagent |
| SMILES string | O=C(CCSSCCC(=O)ON1C(=O)CC |
| solubility | acetone: soluble |
| chloroform: 50 mg/mL | |
| DMF: soluble | |
| storage temp. | −20°C |
| Application: | 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker. |
| Disclaimer: | Avoid use of reducing agents during coupling reactions. |
| Features and Benefits: | The disulfide linkage is cleavable by mild reduction. |
| General description: | 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352106 |