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Doxylamine succinate salt

SIGMA/D3775

CAS Number: 562-10-7
Empirical Formula (Hill Notation): C17H22N2O · C4H6O4
Molecular Weight: 388.46
EC Number: 209-228-7
MDL Number: MFCD00056168
Linear Formula: C17H22N2O · C4H6O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D3775-5G 5 g
 $95.30
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45-D3775-50G 50 g
 $538.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D3775-50G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D3775-5G

 

form powder
InChI 1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI key KBAUFVUYFNWQFM-UHFFFAOYSA-N
originator Sanofi Aventis
Quality Level 200 
SMILES string OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2
Application: Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Application: Doxylamine succinate salt has been used to study the effects of non-teratogenic exposures on morphology and gene expression in human embryonic stem cell aggregates (HESCA)-CSR, under low concentration of retinoic acid in CS medium.
Biochem/physiol Actions: H1 histamine receptor antagonist; hypnotic.
Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.
Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.
Features and Benefits: This compound was developed by Sanofi Aventis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Doxylamine belongs to the ethanolaime class of antihistamines and is metabolized by the liver into N-demethyl doxylamine and N,N-didemethyl doxylamine. It is generally available as an over the counter (OTC) drug for allergy and cold symptoms.
Packaging: 5, 50 g in glass bottle
UNSPSC 12352116

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