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Devazepide

SIGMA/D3821 - ≥98% (HPLC), powder

Synonym: (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide; L-364,718; MK 329

CAS Number: 103420-77-5
Empirical Formula (Hill Notation): C25H20N4O2
Molecular Weight: 408.45
MDL Number: MFCD00864500
Linear Formula: C25H20N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D3821-5MG 5 mg
 $227.00
1/EA		 Add To Favorites
45-D3821-25MG 25 mg
 $909.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
InChI key NFHRQQKPEBFUJK-HSZRJFAPSA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 100 
SMILES string CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15
solubility DMSO: >5 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Devazepide has been used as a cholecystokinin receptor 1 (CCK1R) antagonist in human embryonic kidney 293T cells and in human pancreatic slices.
Biochem/physiol Actions: Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist.
Biochem/physiol Actions: Devazepide is a CCK1 receptor antagonist.
Biochem/physiol Actions: Devazepide is a cholecystokinin octapeptide (CCK1) (CCK-A) receptor antagonist. It inhibits CCK binding to peripheral-type receptor (CCK-A). Devazepide reverses the cholecystokinin octapeptide (CCK-8) based antagonism towards morphine.
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone.
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H300
Precautionary statements P264 - P301 + P310
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 2811 6.1 / PGI
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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