Dansylcadaverine
SIGMA/D4008 - ≥97% (TLC)
Synonym: N-
CAS Number: 10121-91-2
Empirical Formula (Hill Notation): C17H25N3O2S
Molecular Weight: 335.46
EC Number: 233-326-9
MDL Number: MFCD00042704
Linear Formula: C17H25N3O2S
Product Type: Chemical
| assay | ≥97% (TLC) |
| form | powder |
| InChI | 1S/C17H25N3O2S/c1-20(2)16 |
| InChI key | MLEBFEHOJICQQS-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CN(C)c1cccc2c(cccc12)S(=O |
| storage temp. | −20°C |
| Application: | Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used: • as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63) • to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64) • in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65) |
| Biochem/physiol Actions: | The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids. |
| General description: | Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated. |
| Other Notes: | Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid. |
| Packaging: | air sensitive, handled under inert gas |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |