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Dansylcadaverine

SIGMA/D4008 - ≥97% (TLC)

Synonym: N-(5-Amino­pentyl)-5-di­methyl­amino­naphtha­lene-1-sulfon­amide; N-(Dimethyl­amino­naphtha­lene­sulfonyl)-1,5-pentane­diamine; Monodansyl cadaverine

CAS Number: 10121-91-2
Empirical Formula (Hill Notation): C17H25N3O2S
Molecular Weight: 335.46
EC Number: 233-326-9
MDL Number: MFCD00042704
Linear Formula: C17H25N3O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D4008-100MG 100 mg
 $45.60
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45-D4008-250MG 250 mg
 $85.30
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45-D4008-1G 1 g
 $254.00
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assay ≥97% (TLC)
form powder
InChI 1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key MLEBFEHOJICQQS-UHFFFAOYSA-N
Quality Level 100 
SMILES string CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
storage temp. −20°C
Application: Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:
• as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)
• to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)
• in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)
Biochem/physiol Actions: The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
General description: Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.
Other Notes: Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.
Packaging: air sensitive, handled under inert gas
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Purity ≥97% (TLC)
Storage Temp. −20°C
UNSPSC 12352108

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