5,5-Diphenylhydantoin sodium salt

SIGMA/D4505 - ≥99%

Synonym: 5,5-Diphenyl-2,4-imidazolidinedione; Phenytoin

CAS Number: 630-93-3
Empirical Formula (Hill Notation): C₁₅H₁₁N₂NaO₂
Molecular Weight: 274.25
EC Number: 211-148-2
MDL Number: MFCD00069674
Linear Formula: C₁₅H₁₁N₂O₂Na
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-D4505-25G	25 g	$70.00 1/EA		Add To Favorites
45-D4505-100G	100 g	$164.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99%
form	powder
InChI	1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI key	FJPYVLNWWICYDW-UHFFFAOYSA-M
Quality Level	200
SMILES string	[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
solubility	aqueous base: soluble

Application:	5,5-Diphenylhydantoin sodium salt has been used: • in the cream preparation for treating burn wounds • in seizure behavior testing as an anticonvulsant in Drosophila • in in vivo embryo toxicity test in mouse embryonic stem cells
Biochem/physiol Actions:	Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.
Biochem/physiol Actions:	Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.
Features and Benefits:	This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H317 - H361
Precautionary statements	P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
Hazard Codes	Xn
Risk Statements	63-22-43-62
Safety Statements	22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99%
UNSPSC	12352200

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