Dendrotoxin-K
SIGMA/D4813 - ≥98% (HPLC), lyophilized powder
MDL Number: MFCD01866187
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| form | lyophilized powder |
| mol wt | 6,542 Da |
| Quality Level | 200  |
| storage temp. | −20°C |
| Application: | Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice. |
| Biochem/physiol Actions: | Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors. |
| Biochem/physiol Actions: | Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Other Notes: | Isolated initially from Dendroaspis polylepis polylepis venom |
| Preparation Note: | Purified by a modification of the method of Schweitz. |
| Preparation Note: | Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |