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5′-Deoxy-5′-(methylthio)adenosine

SIGMA/D5011

Synonym: Methylthioadenosine; MTA

CAS Number: 2457-80-9
Empirical Formula (Hill Notation): C11H15N5O3S
Molecular Weight: 297.33
MDL Number: MFCD00010533
Linear Formula: C11H15N5O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5011-25MG 25 mg
 $76.40
1/EA		 Add To Favorites
45-D5011-100MG 100 mg
 $229.00
1/EA		 Add To Favorites
45-D5011-250MG 250 mg
 $405.00
1/EA		 Add To Favorites
45-D5011-1G 1 g
 $1180.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5011-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5011-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5011-250MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5011-25MG

 

assay ≥98% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key WUUGFSXJNOTRMR-IOSLPCCCSA-N
Quality Level 200 
SMILES string CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
solubility DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp. −20°C
Application: 5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells. It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.
Biochem/physiol Actions: 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
Packaging: 1 g in poly bottle
Packaging: 25, 100, 250 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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