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DPQ

SIGMA/D5314 - ≥98% (HPLC), solid

Synonym: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone

CAS Number: 129075-73-6
Empirical Formula (Hill Notation): C18H26N2O2
Molecular Weight: 302.41
MDL Number: MFCD01866274
Linear Formula: C18H26N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5314-1MG 1 mg
 $114.00
1/EA		 Add To Favorites
45-D5314-5MG 5 mg
 $387.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
biological source synthetic (organic)
form solid
InChI 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
InChI key RVOUDNBEIXGHJY-UHFFFAOYSA-N
mp 107-109  °C
Quality Level 200 
SMILES string N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
solubility DMSO: 1 mg/mL, clear, colorless to faintly yellow
storage temp. 2-8°C
Application: DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
Biochem/physiol Actions: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
Biochem/physiol Actions: DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
mp 107-109  °C
Storage Temp. 2-8°C
UNSPSC 12352200

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