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7,8-Dihydroxyflavone hydrate

SIGMA/D5446 - ≥98% (HPLC)

CAS Number: 38183-03-8 (anhydrous)
Empirical Formula (Hill Notation): C15H10O4 · xH2O
Molecular Weight: 254.24 (anhydrous basis)
EC Number: 253-812-4
MDL Number: MFCD00006836
Linear Formula: C15H10O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5446-10MG 10 mg
 $92.80
1/EA		 Add To Favorites
45-D5446-50MG 50 mg
 $351.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChI key COCYGNDCWFKTMF-UHFFFAOYSA-N
Quality Level 100 
SMILES string Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3
solubility DMSO: 24 mg/mL
storage condition desiccated
storage temp. room temp
Application: 7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).
Biochem/physiol Actions: 7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.
Biochem/physiol Actions: 7,8-Dihydroxyflavone is a selective TrkB receptor agonist
Biochem/physiol Actions: 7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.
Packaging: 10, 50 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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