7,8-Dihydroxyflavone hydrate
SIGMA/D5446 - ≥98% (HPLC)
CAS Number: 38183-03-8 (anhydrous)
Empirical Formula (Hill Notation): C15H10O4 · xH2O
Molecular Weight: 254.24 (anhydrous basis)
EC Number: 253-812-4
MDL Number: MFCD00006836
Linear Formula: C15H10O4 · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| InChI | 1S/C15H10O4/c16-11-7-6-10 |
| InChI key | COCYGNDCWFKTMF-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Oc1ccc2C(=O)C=C(Oc2c1O)c3 |
| solubility | DMSO: 24 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | 7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kina |
| Biochem/physiol Actions: | 7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction. |
| Biochem/physiol Actions: | 7,8-Dihydroxyflavone is a selective TrkB receptor agonist |
| Biochem/physiol Actions: | 7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential. |
| Packaging: | 10, 50 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |