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N-Desmethylclozapine

SIGMA/D5676

Synonym: 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine; Norclozapine; Normethylclozapine

CAS Number: 6104-71-8
Empirical Formula (Hill Notation): C17H17ClN4
Molecular Weight: 312.80
MDL Number: MFCD00210189
Linear Formula: C17H17ClN4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5676-5MG 5 mg
 $164.00
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45-D5676-10MG 10 mg
 $244.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5676-10MG

 

drug control regulated under CDSA - not available from Sigma-Aldrich Canada
form powder
InChI 1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key JNNOSTQEZICQQP-UHFFFAOYSA-N
Quality Level 200 
SMILES string Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
Application: N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients.
Biochem/physiol Actions: Major metabolite of clozapine; potent 5-HT2 serotonin receptor antagonist and a ligand for the cloned 5-HT6 and 5-HT7 serotonin receptors. Also an allosteric potentiator of M1 muscarinic receptors.
Biochem/physiol Actions: N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors.
Packaging: 5, 10 mg in glass bottle
UNSPSC 12352200

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