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Diacylglycerol Kinase Inhibitor II

SIGMA/D5794 - solid

Synonym: 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone; R59949

CAS Number: 120166-69-0
Empirical Formula (Hill Notation): C28H25F2N3OS
Molecular Weight: 489.58
MDL Number: MFCD00069258
Linear Formula: C28H25F2N3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5794-1MG 1 mg
 $62.00
1/EA		 Add To Favorites
45-D5794-5MG 5 mg
 $178.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
biological source synthetic (organic)
color pale yellow
form solid
InChI 1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
InChI key ZCNBZFRECRPCKU-UHFFFAOYSA-N
mp 228-230  °C
Quality Level 200 
SMILES string Fc1ccc(cc1)C(=C2CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5
solubility 0.1 M HCl: slightly soluble
  0.1 M NaOH: slightly soluble
  DMSO: soluble
  ethanol: soluble
  ethyl acetate: soluble
  H2O: insoluble
storage temp. −20°C
Application: Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.
Biochem/physiol Actions: Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥97% (HPLC)
mp 228-230  °C
Storage Temp. −20°C
UNSPSC 41106300

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