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DMXAA

SIGMA/D5817 - ≥98% (HPLC), solid

Synonym: 5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan

CAS Number: 117570-53-3
Empirical Formula (Hill Notation): C17H14O4
Molecular Weight: 282.29
MDL Number: MFCD00870555
Linear Formula: C17H14O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5817-5MG 5 mg
 $263.00
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45-D5817-25MG 25 mg
 $900.00
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assay ≥98% (HPLC)
color light brown
form solid
InChI 1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
InChI key XGOYIMQSIKSOBS-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1ccc2C(=O)c3cccc(CC(O)=O)c3Oc2c1C
solubility DMSO: soluble >10 mg/mL
storage temp. 2-8°C
Application: 5,6-dimethylxanthenone-4-acetic acid (DMXAA) has been used to induce type-I IFN signaling in a stimulator of interferon genes (STING) dependent manner. It has also been used to study STING-dependent signaling in the absence of infection.
Biochem/physiol Actions: DMXAA is an apoptosis inducer; anti-vascular.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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