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1,1-Dimethyl-4-phenylpiperazinium iodide

SIGMA/D5891 - ≥98% (TLC or titration)

Synonym: DMPP

CAS Number: 54-77-3
Empirical Formula (Hill Notation): C12H19IN2
Molecular Weight: 318.20
EC Number: 200-213-0
MDL Number: MFCD00011976
Linear Formula: C12H19IN2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5891-1G 1 g
 $55.40
1/EA		 Add To Favorites
45-D5891-10G 10 g
 $302.00
1/EA		 Add To Favorites

 

assay ≥98% (TLC or titration)
form powder
InChI 1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI key XFZJGFIKQCCLGK-UHFFFAOYSA-M
mp 234-238 °C (lit.)
Quality Level 200 
SMILES string [I-].C[N+]1(C)CCN(CC1)c2ccccc2
solubility H2O: 21 mg/mL
storage temp. −20°C
Application: 1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:
•  to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
•  to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
•  to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon
Biochem/physiol Actions: 1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Nicotinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1, 10 g in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC or titration)
mp 234-238 °C (lit.)
Storage Temp. −20°C
UNSPSC 12352200

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