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Diacylglycerol Kinase Inhibitor I

SIGMA/D5919 - solid

Synonym: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidin­yl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one; R59022

CAS Number: 93076-89-2
Empirical Formula (Hill Notation): C27H26FN3OS
Molecular Weight: 459.58
MDL Number: MFCD00055114
Linear Formula: C27H26FN3OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D5919-1MG 1 mg
 $131.00
1/EA		 Add To Favorites
45-D5919-5MG 5 mg
 $452.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
biological source synthetic (organic)
color pale yellow
form solid
InChI 1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
InChI key MFVJXLPANKSLLD-UHFFFAOYSA-N
Quality Level 200 
SMILES string CC1=C(CCN2CCC(CC2)=C(c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
solubility 0.1 M HCl: slightly soluble
  0.1 M NaOH: slightly soluble
  DMSO: soluble
  ethanol: soluble
  ethyl acetate: soluble
  H2O: insoluble
storage temp. −20°C
Application: Diacylglycerol Kinase Inhibitor I has been used as an inhibitor to study suppression of T cell function using advanced generation human CAR (chimeric antigen receptors) T cells.
Biochem/physiol Actions: Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoxyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
General description: Diacylglycerol Kinase Inhibitor I prevents the formation of foreign body giant cell (FBGC). It inhibits the phosphorylation of diacylglycerol to phosphatidic acid. Diacylglycerol Kinase Inhibitor I functions as a serotonin (5-HT) receptor (5-HTR) antagonist. It stimulates apoptosis and autophagy in neuronal cell line NG108-15.
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106300

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