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Demeclocycline hydrochloride

SIGMA/D6140 - powder or crystals

Synonym: 7-Chloro-6-demethyltetracycline hydrochloride; Demethylchlorotetracycline hydrochloride

CAS Number: 64-73-3
Empirical Formula (Hill Notation): C21H21ClN2O8 · HCl
Molecular Weight: 501.31
EC Number: 200-592-2
MDL Number: MFCD00082371
Linear Formula: C21H21ClN2O8 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D6140-1G 1 g
 $262.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
assay 89.5-102.0% anhydrous basis
form powder or crystals
InChI 1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
InChI key GVSJQNRGSCOSNJ-KBHRXELFSA-N
mode of action protein synthesis | interferes
Quality Level 200 
SMILES string Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
solubility soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
storage temp. −20°C
technique(s) cell culture | mammalian: suitable
Biochem/physiol Actions: Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Biochem/physiol Actions: Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Biochem/physiol Actions: Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.
General description: Chemical structure: tetracycline
Purity 89.5-102.0% anhydrous basis
Storage Temp. −20°C
UNSPSC 12352207

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