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Dimebon dihydrochloride hydrate

SIGMA/D6196 - ≥98% (HPLC)

Synonym: 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate; Dimebolin dihydrochloride hydrate; Dimeboline dihydrochloride hydrate; Dimebone dihydrochloride hydrate

CAS Number: 97657-92-6 (anhydrous)
Empirical Formula (Hill Notation): C21H25N3 · 2HCl · xH2O
Molecular Weight: 392.37 (anhydrous basis)
MDL Number: MFCD17215933
Linear Formula: C21H25N3 · 2HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D6196-5MG 5 mg
 $152.00
1/EA		 Add To Favorites
45-D6196-25MG 25 mg
 $597.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
InChI key QQHQMWVYYVVAOV-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
solubility H2O: ≥10 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.
Features and Benefits: This compound is featured on the Calcium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302 - H315 - H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xn
Risk Statements 22-36/38
Safety Statements 26-36/39
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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