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Donepezil hydrochloride

SIGMA/D6821 - ≥98% (HPLC)

Synonym: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride; E2020

CAS Number: 120011-70-3
Empirical Formula (Hill Notation): C24H29NO3 · HCl
Molecular Weight: 415.95
MDL Number: MFCD00881312
Linear Formula: C24H29NO3 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D6821-10MG 10 mg
 $84.40
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45-D6821-50MG 50 mg
 $341.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D6821-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D6821-50MG

 

assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
InChI key HLJIZAKUNCTCQX-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
solubility DMSO: ≥20 mg/mL
  H2O: ≥20 mg/mL
storage condition desiccated
storage temp. room temp
Application: Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice. It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.
Biochem/physiol Actions: Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor. It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom. Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.
Biochem/physiol Actions: Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.
Biochem/physiol Actions: Donepezil monohydrochloride monohydrate is a reversible acetylcholinesterase inhibitor
Features and Benefits: This compound is featured on the Acetylcholine Synthesis and Metabolism  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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