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Dihydrofolic acid

SIGMA/D7006 - ≥90%

Synonym: 7,8-Dihydropteroyl-L-glutamic acid; Dihydropteroyl-L-glutamic acid; FAH2

CAS Number: 4033-27-6
Empirical Formula (Hill Notation): C19H21N7O6
Molecular Weight: 443.41
MDL Number: MFCD00083619
Linear Formula: C19H21N7O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D7006-10MG 10 mg
 $140.00
1/EA		 Add To Favorites
45-D7006-25MG 25 mg
 $314.00
1/EA		 Add To Favorites
45-D7006-100MG 100 mg
 $1050.00
1/EA		 Add To Favorites
Representative of vacuum-sealed clear ampule packaging. Non-uniform tips are an inherent feature in this sealing process.

 

assay ≥90%
biological source synthetic (organic)
color light yellow to dark yellow-orange
form powder
InChI 1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
InChI key OZRNSSUDZOLUSN-LBPRGKRZSA-N
Quality Level 200 
SMILES string NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
storage temp. −20°C
Application: Dihydrofolic acid has been used in diaphorase-coupled assay for dihydrofolate reductase (DHFR) activity. It has also been used as a component in assay buffer to determine dihydrofolate reductase (DHFR) activity.
Biochem/physiol Actions: Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).
General description: Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.
Packaging: Sealed ampule.
Purity ≥90%
Storage Temp. −20°C
UNSPSC 12352106

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