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L-Dihydroorotic acid

SIGMA/D7128 - ≥99%

Synonym: 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid; L-Hydroorotic acid; Dihydro-L-orotic acid

CAS Number: 5988-19-2
Empirical Formula (Hill Notation): C5H6N2O4
Molecular Weight: 158.11
MDL Number: MFCD00085339
Linear Formula: C5H6N2O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D7128-500MG 500 mg
 $177.00
1/EA		 Add To Favorites
45-D7128-1G 1 g
 $314.00
1/EA		 Add To Favorites
45-D7128-5G 5 g
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D7128-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D7128-500MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D7128-5G

 

assay ≥99%
form powder
InChI 1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
InChI key UFIVEPVSAGBUSI-REOHCLBHSA-N
mp 254-255 °C (dec.) (lit.)
Quality Level 200 
SMILES string OC(=O)[C@@H]1CC(=O)NC(=O)N1
Application: L-Dihydroorotic acid has been used as a substrate in dihydroorotate dehydrogenase (DHODH) assay.
Biochem/physiol Actions: L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
Packaging: 1, 5 g in poly bottle
Packaging: 500 mg in poly bottle
Purity ≥99%
mp 254-255 °C (dec.) (lit.)
UNSPSC 12352204

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