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Dynasore hydrate

SIGMA/D7693

Synonym: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate

CAS Number: 1202867-00-2
Empirical Formula (Hill Notation): C18H14N2O4 · xH2O
Molecular Weight: 322.31 (anhydrous basis)
MDL Number: MFCD11045288
Linear Formula: C18H14N2O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D7693-5MG 5 mg
 $123.00
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45-D7693-25MG 25 mg
 $503.00
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color off-white
form powder
InChI 1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI key FKWZHQSDBMSHTN-ZIOFAICLSA-N
Quality Level 100 
SMILES string O.Oc1ccc(C=NNC(=O)c2cc3ccccc3cc2O)cc1O
solubility DMSO: ≥10 mg/mL
  H2O: insoluble
storage condition protect from light
storage temp. −20°C
Application: Dynasore hydrate has been used:
• for priming fetal mesenchymal stem/stromal cells (fMSC)
• in confocal microscopy
• in wound healing/scratch and tube-formation assay
• to analyse its effects on Coxsackievirus A9 (CAV9) infection
• to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
• in live imaging of cells
Biochem/physiol Actions: Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Packaging: 5, 25 mg in glass bottle
Symbol GHS09  GHS09
Signal word Warning
Hazard statements H400
Precautionary statements P273
Hazard Codes N
Risk Statements 50
Safety Statements 22-24/25-61
RIDADR UN 3077 9 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352200

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