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Pyrroloquinoline quinone

SIGMA/D7783 - ≥95.0% (HPLC)

Synonym: 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid; Methoxatin; PQQ

CAS Number: 72909-34-3
Empirical Formula (Hill Notation): C14H6N2O8
Molecular Weight: 330.21
MDL Number: MFCD00043125
Linear Formula: C14H6N2O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D7783-1MG 1 mg
 $185.00
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45-D7783-5MG 5 mg
 $527.00
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45-D7783-10MG 10 mg
 $923.00
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assay ≥95.0% (HPLC)
biological source synthetic
color red to deep red
form powder
InChI 1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24)
InChI key MMXZSJMASHPLLR-UHFFFAOYSA-N
Quality Level 200 
SMILES string OC(=O)c1cc(C(O)=O)c-2c(n1)C(=O)C(=O)c3cc([nH]c-23)C(O)=O
storage temp. 2-8°C
technique(s) HPLC: suitable
Application: Pyrroloquinoline quinone has been used:
• as a component of nanocurcumin formulation (NCF), to study its therapeutic effect on ameliorate hypoxia-induced stress in hypertrophied cardiomyocytes
• as a standard in fluorescence analysis
• to test its efficiency in suppressing restrained oxidative stress and hepatic fibrogenesis in mouse models
Biochem/physiol Actions: PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.
Biochem/physiol Actions: Pyrroloquinoline Quinone (PQQ) plays a vital role in gluconic acid production and biosynthesis by microbes. It acts as an effective microbial growth stimulant and biological control determinant for plant pathogens. PQQ also acts as an anti-melanogenic agent and is used to treat disorders related to hyper pigmentation. It exhibits diverse role in metabolism and cell signaling pathways. PQQ is used as a potential therapeutic to treat liver fibrosis.
General description: Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.
General description: Pyrroloquinoline Quinone (PQQ), also referred as methoxatin, is a water soluble orthoquinone molecule with redox-cycling ability.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352106

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