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dPPA

SIGMA/D7821 - ≥98% (HPLC)

Synonym: 12-Deoxyphorbol 13-phenylacetate 20-acetate; DOPPA

CAS Number: 54662-30-5
Empirical Formula (Hill Notation): C30H36O7
Molecular Weight: 508.60
MDL Number: MFCD01741294
Linear Formula: C30H36O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D7821-1MG 1 mg
 $197.00
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assay ≥98% (HPLC)
color colorless to light yellow
form oil
InChI 1S/C30H36O7/c1-17-11-23-28(34,26(17)33)15-21(16-36-19(3)31)12-22-25-27(4,5)29(25,14-18(2)30(22,23)35)37-24(32)13-20-9-7-6-8-10-20/h6-12,18,22-23,25,34-35H,13-16H2,1-5H3/t18-,22+,23-,25-,28-,29+,30-/m1/s1
InChI key MEDVHSNRBPAIPU-XMOZQXTISA-N
Quality Level 100 
SMILES string CC(C1=O)=C[C@]2([H])[C@]1(O)CC(COC(C)=O)=C[C@]3([H])[C@]2(O)[C@H](C)C[C@]4(OC(CC5=CC=CC=C5)=O)[C@H]3C4(C)C
storage temp. −20°C
Application: dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
• to treat transfected HT-22 cells to promote phosphorylation of p66Shc
• to treat HT-22 and B12 cells to study its effects on cell viability
• to treat neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay
Biochem/physiol Actions: dPPA is a phorbol ester that selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the α, γ or δ isotypes. PKC family members each have specific functions, but PKC-β and δ appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCβ specific signaling events.
Features and Benefits: This compound is featured on the PKC  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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