2-Deoxy-D-glucose

SIGMA/D8375 - ≥98% (GC), crystalline

Synonym: 2-Deoxyglucose; 2-Deoxy-D-arabinohexose

CAS Number: 154-17-6
Empirical Formula (Hill Notation): C₆H₁₂O₅
Molecular Weight: 164.16
EC Number: 205-823-0
MDL Number: MFCD00151328
Linear Formula: C₆H₁₂O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D8375-10MG	10 mg	$36.00 1/EA	Add To Favorites
45-D8375-1G	1 g	$101.00 1/EA	Add To Favorites
45-D8375-5G	5 g	$343.00 1/EA	Add To Favorites
45-D8375-25G	25 g	$1470.00 1/EA	Add To Favorites
45-D8375-100G	100 g	$3120.00 1/EA	Add To Favorites

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This image depicts SKU: D8375-25G

Properties
Descriptions
Safety Info.
Basic Data

application(s)	clinical research life science and biopharma metabolomics
assay	≥98% (GC)
biological source	synthetic
color	white to off-white
form	crystalline
InChI	1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
InChI key	VRYALKFFQXWPIH-PBXRRBTRSA-N
mp	146-147 °C (lit.)
Quality Level	200
SMILES string	OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
solubility	H₂O: 0.250 g/5mL
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	inhibition assay: suitable

Application:	2-Deoxy-D-glucose (2-DG) is used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR). 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions:	2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.
Features and Benefits:	• High-purity compound suitable for a wide variety of research applications
General description:	2-Deoxy-D-glucose, a non-metabolizable glucose analogue, disrupts glycolysis by targeting hexokinase, the rate-limiting step in glycolysis. Phosphorylated to 2-DG-P by hexokinase, it accumulates in the cell, depleting cellular ATP. This approach, effective in starving and killing cancer cells, may also inhibit virus cells reliant on glycolysis for replication. This versatile molecule finds application in cancer, virology, metabolomics and biochemical research.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Other Notes:	To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	1, 5, 25, 100 g in poly bottle
Packaging:	10 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (GC)
mp	146-147 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352201

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