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15-Deoxy-Δ12,14-prostaglandin J2

SIGMA/D8440 - ≥95% (HPLC), 1 mg/mL in methyl acetate

Synonym: 11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid; 15-Deoxy-Δ12,14-PGJ2

CAS Number: 87893-55-8
Empirical Formula (Hill Notation): C20H28O3
Molecular Weight: 316.43
EC Number: 201-185-2
MDL Number: MFCD00065806
Linear Formula: C20H28O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D8440-100UG 100 µg
 $48.70
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assay ≥95% (HPLC)
concentration 1 mg/mL in methyl acetate
form liquid
InChI 1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1
InChI key VHRUMKCAEVRUBK-GODQJPCRSA-N
Quality Level 200 
shipped in wet ice
SMILES string CCCCCC=CC=C1/[C@@H](CC=C/CCCC(O)=O)C=CC1=O
storage temp. −20°C
Application: 15-Deoxy-Δ12,14-prostaglandin J2 has been used:
• to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
•  as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
•  as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
Biochem/physiol Actions: 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
Biochem/physiol Actions: Selective agonist to PPARγ (peroxisome proliferator-activated receptors). Inhibits the proliferation of cancer cell lines that express PPARγ and cyclooxygenase-2 (COX-2).
General description: 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a prostaglandin J2 (PGJ2) metabolite and a naturally occurring derivative of prostaglandin D2. It is produced during inflammatory processes.
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352211

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