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P7C3

SIGMA/D8446 - ≥98% (HPLC)

Synonym: 3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol

CAS Number: 301353-96-8
Empirical Formula (Hill Notation): C21H18Br2N2O
Molecular Weight: 474.19
MDL Number: MFCD00572918
Linear Formula: C21H18Br2N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D8446-5MG 5 mg
 $147.00
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45-D8446-25MG 25 mg
 $578.00
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
InChI key FZHHRERIIVOATI-UHFFFAOYSA-N
Quality Level 100 
SMILES string OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
solubility DMSO: 34 mg/mL
storage temp. 2-8°C
Application: P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.
Biochem/physiol Actions: P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.
Biochem/physiol Actions: P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.

Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352203

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