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7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

SIGMA/D8783 - 10 mM in H2O

Synonym: −N7-dGTP; 7-Deaza-dGTP

CAS Number: 101515-08-6
Empirical Formula (Hill Notation): C11H17N4O13P3
Molecular Weight: 506.19
MDL Number: MFCD00171614
Linear Formula: C11H17N4O13P3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D8783-.5UMO 0.5 µmol
 $153.00
1/EA		 Add To Favorites
Representative packaging

 

assay ≥95% (HPLC)
biological source Porcine muscle
  rabbit muscle
color colorless
concentration 10 mM in H2O
form liquid
InChI 1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)
InChI key DLLXAZJTLIUPAI-UHFFFAOYSA-N
Quality Level 200 
shipped in dry ice
SMILES string NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1
storage temp. −20°C
Application: 7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt has been used as a lysis agent to evaluate its efficiency on direct cell lysis, RNA stability, and compatibility with downstream reverse transcription quantitative real-time PCR during the analyzes of samples with small numbers of cells.
Biochem/physiol Actions: 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-deaza-dGTP) competes with natural substrate dGTP and blocks the telomerase activity. This nucleotide once incorporated into the telomere alters the secondary structure of the telomere making it difficult for telomerase to identify it for further telomere synthesis. This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA polymerases. 7-deaza-dGTP in combination with dimethyl sulfoxide (DMSO) and betaine enhances the polymerase chain reaction (PCR) amplification of GC-rich DNA sequences.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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