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Dexamethasone

SIGMA/D8893 - powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F

CAS Number: 50-02-2
Empirical Formula (Hill Notation): C22H29FO5
Molecular Weight: 392.46
EC Number: 200-003-9
MDL Number: MFCD00064136
Linear Formula: C22H29FO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D8893-1MG 1 mg
 $70.90
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assay ≥80% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key UREBDLICKHMUKA-CXSFZGCWSA-N
mp 262-264 °C (lit.)
potency 4-500 ng/mL
product line BioXtra
Quality Level 200 
shipped in ambient
SMILES string C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
solubility ethanol: 1 mL/vial, clear
sterility γ-irradiated
storage temp. 2-8°C
technique(s) cell culture | mammalian: suitable
Application: Dexamethasone has been used as a component of osteogenic differentiation medium. It has also been used to study apoptosis, cell signaling pathways and gene expression.
Biochem/physiol Actions: Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins. It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.
Biochem/physiol Actions: Glucocorticoid anti-inflammatory agent
Biochem/physiol Actions: Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
Physical form: powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note: To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.
Purity ≥80% (HPLC)
mp 262-264 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352209

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