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Diazoxide

SIGMA/D9035

Synonym: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

CAS Number: 364-98-7
Empirical Formula (Hill Notation): C8H7ClN2O2S
Molecular Weight: 230.67
EC Number: 206-668-1
MDL Number: MFCD00078578
Linear Formula: C8H7ClN2O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D9035-250MG 250 mg
 $110.00
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45-D9035-1G 1 g
 $366.00
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45-D9035-5G 5 g
 $1330.00
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form powder
InChI 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChI key GDLBFKVLRPITMI-UHFFFAOYSA-N
originator Schering Plough
Quality Level 100 
SMILES string CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
solubility 0.1 M NaOH: soluble
  H2O: insoluble
  methanol: soluble
Application: Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K+-induced exocytosis.
Biochem/physiol Actions: Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Schering Plough . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell KATP channel opener. Diazoxide prevents the secretion of insulin.
UNSPSC 12352119

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