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2,3-Dimethoxy-5-methyl-p-benzoquinone

SIGMA/D9150 - apoptosis inducer

Synonym: Coenzyme Q0

CAS Number: 605-94-7
Empirical Formula (Hill Notation): C9H10O4
Molecular Weight: 182.17
EC Number: 210-100-8
MDL Number: MFCD00001595
Linear Formula: C9H10O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D9150-1G 1 g
 $83.90
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45-D9150-5G 5 g
 $285.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D9150-1G

 

form powder
InChI 1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
InChI key UIXPTCZPFCVOQF-UHFFFAOYSA-N
mp 58-60 °C (lit.)
Quality Level 200 
SMILES string COC1=C(OC)C(=O)C(C)=CC1=O
storage temp. 2-8°C
Application: 2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:
• as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
• as a component in buffer B for cytochrome oxidation assay with subsaturating light
• in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity
Application: Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.
Biochem/physiol Actions: 2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.
General description: 2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.
Packaging: 1, 5 g in glass bottle
mp 58-60 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352204

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