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1-Deoxymannojirimycin hydrochloride

SIGMA/D9160

Synonym: 1-Deoxymannojirimycin HCl; 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

CAS Number: 73465-43-7
Empirical Formula (Hill Notation): C6H13NO4 · HCl
Molecular Weight: 199.63
MDL Number: MFCD00083611
Linear Formula: C6H13NO4 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D9160-1MG 1 mg
 $158.00
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45-D9160-5MG 5 mg
 $422.00
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45-D9160-10MG 10 mg
 $826.00
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antibiotic activity spectrum viruses
color white to off-white
form powder
InChI 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
InChI key ZJIHMALTJRDNQI-MVNLRXSJSA-N
mode of action enzyme | inhibits
Quality Level 200 
SMILES string Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
solubility H2O: 10 mg/mL
storage temp. 2-8°C
Application: 1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.
Biochem/physiol Actions: 1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.
Biochem/physiol Actions: Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.
General description: Chemical structure: glucosamine
Packaging: 1, 5 mg in glass bottle
Packaging: 10 mg in poly bottle
Storage Temp. 2-8°C
UNSPSC 51102829

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