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DL-Dithiothreitol

SIGMA/D9163 - suitable for electrophoresis, ≥99%

Synonym: threo-1,4-Dimercapto-2,3-butanediol; Cleland’s reagent; DTT

CAS Number: 3483-12-3
Empirical Formula (Hill Notation): C4H10O2S2
Molecular Weight: 154.25
EC Number: 222-468-7
MDL Number: MFCD00004877
Linear Formula: HSCH2CH(OH)CH(OH)CH2SH
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D9163-1G 1 g
 $64.90
1/EA		 Add To Favorites
45-D9163-5G 5 g
 $190.00
1/EA		 Add To Favorites
45-D9163-25G 25 g
 $735.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D9163-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D9163-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: D9163-5G

 

absorption ≤0.04 at 280 at 0.02 M
assay ≥99%
cation traces heavy metals (as Pb): ≤10 ppm
form powder
InChI 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
InChI key VHJLVAABSRFDPM-QWWZWVQMSA-N
mp 40-44 °C
  41-44 °C (lit.)
Quality Level 200 
reaction suitability reagent type: reductant
SMILES string O[C@H](CS)[C@H](O)CS
solubility H2O: 50 mg/mL, clear, colorless to very faintly yellow
storage temp. 2-8°C
technique(s) electrophoresis: suitable
Analysis Note: Tested for use in reduced SDS-PAGE
Application: An excellent reagent for maintaining SH groups in reduced state; quantitatively reduces disulfides. DTT is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N′-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel. DTT is less pungent and is less toxic than 2-mercaptoethanol. Typically, a seven fold lower concentration of DTT (100 mM) is needed than is used for 2-mercaptoethanol (5% v/v, 700 mM).
Packaging: 1, 5, 25 g in poly bottle
Purity ≥99%
mp 40-44 °C; 41-44 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12161504

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