Dexamethasone

SIGMA/D9184 - meets USP testing specifications

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F

CAS Number: 50-02-2
Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
Molecular Weight: 392.46
EC Number: 200-003-9
MDL Number: MFCD00064136
Linear Formula: C₂₂H₂₉FO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D9184-100MG	100 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites
45-D9184-1G	1 g	$545.00 1/EA	Add To Favorites
45-D9184-5G	5 g	$2050.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D9184-100MG

Properties
Descriptions
Safety Info.
Basic Data

agency	meets USP testing specifications
	USP/NF
assay	97.0-102.0%
biological source	synthetic (organic)
form	solid
InChI	1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key	UREBDLICKHMUKA-CXSFZGCWSA-N
mp	262-264 °C (lit.)
Quality Level	200
shipped in	ambient
SMILES string	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
storage temp.	2-8°C

Application:	Dexamethasone was used as medium supplement in the following studies: • To investigate the osteogenic differentiation and chondrogenic differentiation of bone marrow mesenchymal stem cells (MSCs). • In α-MEM (minimum essential medium) for inducing the osteogenic and adipogenic differentiation in mesenchymal stem cells from human bone marrow and umbilical cord blood. • For the isolation and characterization of mesenchymal stem cells isolated from 6- to 8-week-old C57BL/6J mice.
Biochem/physiol Actions:	Glucocorticoid anti-inflammatory agent
Biochem/physiol Actions:	Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
General description:	Dexamethasone is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression. It is useful for study of apoptosis, cell signaling pathways and gene expression.
Packaging:	1, 5 g in glass bottle
Packaging:	100 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H360FD
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	22-26-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97.0-102.0%
mp	262-264 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352212

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