Doxycycline hyclate

SIGMA/D9891

Synonym: 6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate; Doxycycline hydrochloride hemiethanolate hemihydrate

CAS Number: 24390-14-5
Empirical Formula (Hill Notation): C₂₂H₂₄N₂O₈ · HCl · 0.5H₂O · 0.5C₂H₆O
Molecular Weight: 512.94
MDL Number: MFCD07357237
Linear Formula: C₂₂H₂₄N₂O₈ · HCl · 0.5H₂O · 0.5C₂H₆O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D9891-1G	1 g	$65.00 1/EA	Add To Favorites
45-D9891-5G	5 g	$154.00 1/EA	Add To Favorites
45-D9891-10G	10 g	$261.00 1/EA	Add To Favorites
45-D9891-25G	25 g	$508.00 1/EA	Add To Favorites
45-D9891-100G	100 g	$1820.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D9891-5G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycoplasma
	parasites
assay	≥93.5% (HPLC)
	95.0-102.0% anhydrous basis (ethanol free based)
biological source	synthetic
color	yellow to yellow-green
form	powder
InChI	1S/2C22H24N2O8.C2H6O.2ClH.H2O/c21-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h24-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;21H;1H2/t27-,10?,14?,15-,17-,22-;;;;/m00..../s1
InChI key	HALQELOKLVRWRI-ZVACAFRPSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
storage condition	(Tightly closed. Dry. )
storage temp.	2-8°C

Application:	Doxycycline hyclate has been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).
Application:	Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling.
Biochem/physiol Actions:	Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Features and Benefits:	• High-quality antibiotic suitable for multiple research applications • Ideal for Cell Biology, Metabolomics, and Biochemical research.
General description:	Doxycycline Hyclate, a synthetic tetracycline antibiotic, demonstrates broad-spectrum antimicrobial activity against various bacteria by binding to the 30S and potentially the 50S ribosomal subunits. This binding disrupts the aminoacyl-tRNA binding to the mRNA-ribosome complex, effectively inhibiting bacterial protein synthesis, thereby halting growth and replication. Beyond its antimicrobial effects, Doxycycline Hyclate serves as an inhibitor of matrix metalloproteinases (MMPs), enzymes crucial for collagen breakdown in connective tissues. Studies on corneal erosion and rheumatoid arthritis showcase its significant reduction in MMP-9 and MMP-8 levels, respectively. This MMP-inhibiting property helps preserve collagen integrity, preventing excessive tissue degradation and supporting tissue repair. In cell biology, Doxycycline Hyclate impacts smooth muscle cells, enhancing adhesion and influencing the reorganization of fibrillar collagen matrices. Its influence on apicoplast gene expression in Plasmodium falciparum, the malaria-causing parasite, adds a dimension of significance in infectious disease research. Additionally, the inhibition of tissue formation in rat studies contributes to its relevance in understanding tissue development. Moreover, Doxycycline Hyclate holds potential in metabolomics research, considering its multi-faceted effects on various cellular processes. In the broader context of biochemical research, its versatile actions make it a valuable tool for investigating molecular mechanisms and signaling pathways.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Other Notes:	For additional information on our range of Biochemicals , please complete this form .
Packaging:	1, 5, 10, 25, 100 g in glass bottle

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥93.5% (HPLC); ≥93.5% (HPLC); 95.0-102.0% anhydrous basis (ethanol free based)
Storage Temp.	2-8°C
UNSPSC	51284027

To Order From a Quote