Carboxylesterase 1 isoform c human
SIGMA/E0162 - recombinant, expressed in baculovirus infected BTI insect cells
Synonym: Carboxylesterase 1 human; carboxylesterase; esterase
EC Number: 232-773-7
Product Type: Chemical
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| concentration | ≥0.3 mg/mL |
| form | liquid |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected BTI insect cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies. |
| Biochem/physiol Actions: | Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs. |
| General description: | Carboxylesterase 1 (CE1) is a member of a large multigene carboxylesterase α,β-hydrolase family. It is majorly expressed in the liver. CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain. |
| General description: | This product is offered in a volume of 0.5 mL. |
| Other Notes: | One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261 - P284 - P304 + P340 + P312 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 3.1.1.1 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |