ER-27319
SIGMA/E0656 - ≥98% (HPLC), solid
Synonym: 10-
CAS Number: 201010-95-9
Empirical Formula (Hill Notation): C20H22N2O5
Molecular Weight: 370.40
MDL Number: MFCD07784502
Linear Formula: C20H22N2O5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| form | solid |
| InChI | 1S/C18H20N2O.C2H2O4/c1-12 |
| InChI key | IIELZHYJYZBSGG-UHFFFAOYSA |
| Quality Level | 100 ![]() |
| SMILES string | OC(=O)C(O)=O.Cc1ccc2C(=O) |
| solubility | DMSO: 28 mg/mL |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk. |
| Biochem/physiol Actions: | Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 25 mg in poly bottle |
| Packaging: | 5 mg in glass bottle |
| Symbol | GHS07 |
| Signal word | Warning |
| Hazard statements | H302 + H312 |
| Precautionary statements | P280 - P301 + P312 + P330 - P302 + P352 + P312 |
| Hazard Codes | Xn |
| Risk Statements | 21/22 |
| Safety Statements | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |


