Epidermal Growth Factor from murine submaxillary gland
SIGMA/E1257 - lyophilized powder, BioReagent, suitable for cell culture
Synonym: EGF; Epidermal cell growth factor
CAS Number: 62229-50-9
EC Number: 263-468-7
MDL Number: MFCD01634807
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (SDS-PAGE) |
| biological source | mouse submaxillary glands |
| color | white |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| packaging | pkg of 0.1 mg |
| potency | 0.02-2.0 ng/mL EC50 |
| product line | BioReagent |
| Quality Level | 200  |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | 2-8°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01132  |
| Analysis Note: | The biological activity is measured in a proliferation assay using BALB/MK cells. |
| Application: | Epidermal Growth Factor from murine submaxillary gland has been used • in studying its effects on the development of caustic esophageal stricture in rats • for preparation of MCF-10A cell line • for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF) |
| Biochem/physiol Actions: | Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development. |
| General description: | Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland. |
| Physical form: | Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer. |
| Preparation Note: | Purified by gel filtration and ion-exchange chromatography. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (SDS-PAGE) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |