Embelin
SIGMA/E1406 - ≥98% (HPLC), powder
Synonym: 2,5-
CAS Number: 550-24-3
Empirical Formula (Hill Notation): C17H26O4
Molecular Weight: 294.39
EC Number: 208-979-8
MDL Number: MFCD00016369
Linear Formula: C17H26O4
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| parasites | |
| assay | ≥98% (HPLC) |
| form | powder |
| InChI | 1S/C17H26O4/c1-2-3-4-5-6- |
| InChI key | IRSFLDGTOHBADP-UHFFFAOYSA |
| mode of action | DNA synthesis | interferes |
| Quality Level | 200  |
| SMILES string | CCCCCCCCCCCC1=C(O)C(=O)C= |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble |
| Application: | Embelin has been used: • to study its effects on the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced nuclear factor of activated T cells (NFATc1) luciferase activity • to study its role in the mechanisms mediating Parkinson′s disease (PD) • in treating whole mouse embryos to determine its effects on the X-linked inhibitory apoptosis protein (XIAP) activity |
| Biochem/physiol Actions: | Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity. |
| Biochem/physiol Actions: | Embelin elicits anti-oxidant, mitochondrial uncoupling, and anti-fertility properties. It also has anti-diabetic, anti-convulsant, anxiolytic, and anti-microbial activities. Embelin acts as a potent neuroprotective agent and is also beneficial as an adjunct therapy for cerebral stroke. |
| General description: | Embelin, a natural benzoquinone-derivative, was initially extracted from Embelia ribes plant. It is structurally similar to ubiquinone. |
| Packaging: | 10 mg in glass bottle |
| Symbol |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361f |
| Precautionary statements | P201 - P308 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |